Fasting and Fisetin

As far as I understand it fasting has a multitude of benefits beyond just losing weight. You have autophagy and apoptosis, an increase in growth hormone, a reduction in insulin resistance, a reduction through the loss of fat in production of oestrogen and much else besides on the cellular level. You’re also reducing or getting rid of that damaging visceral fat. In fact, many new drugs being developed for dealing with what has been dubbed ‘metabolic syndrome’, i.e. poor lifestyle choices, have effects that are the same as those fasting produces. Psychologically you’re taking control of your body and that, though I hate the word, is empowering.

Combine fasting with exercise and the benefits ramp up. I’ve been fasting now for nigh on two months spending two days a week without food. Also, throughout this time, I’ve been walking longish distances at the weekends and hitting the gym for 50mins three to four times every week. I’m steadily closing on having lost 20lbs of fat, feel light and have better muscle definition, and am feeling pretty good about that. But, as ever, I have to go one step further.

My weight loss has been steadily declining. At the start of this fasting period I was losing (if you discount the large water loss) getting on for 3lbs a week. It’s now down to about half that. I know from my reading that the longer you fast the longer you spend in ketosis and autophagy so the greater benefits you get from them. Because Julie was going away this last weekend I decided to go for a four-day fast and see how I got on with that.

Other reading added something else too. I know that to retard the effects of aging and for good health, weight loss (best through fasting) and exercise are two of the things we as individuals can do. But now another looms on the horizon. A lot, if not most, of the damage of aging comes from senescent cells. These are cells that have malfunctioned but, due to the nature of that malfunction, have not been destroyed by the body. They sit inside us producing SASP – Senescent-Associated Secretory Phenotype – which causes inflammation and has been linked to many disorders. Now studies have shown that by using a senolytic – a drug that causes apoptosis (death) of these malfunctioning cells – one can to a degree reverse some of the effects of aging.

Few senolytics are available. The most effective (in mouse studies) has been a combination of a cancer drug called dasatinib and an over-the-counter supplement called quercetin. The quercetin doesn’t do very much by itself. But there are others that are easily available to us. One is in long pepper – a substance called piperlongumin. Another is fisetin – the flavonoid that gives strawberries their colour. Apparently this last may be best of all and can work without a toxic cancer drug involved. So I decided to use some.

Apparently just a few fisetin capsules don’t have the required senolytic effect. You need to megadose with it, but this stuff supposedly has nothing in the way of adverse side effects. My searches and calculations gave me a dosage of 640mg of pure fisetin (the capsules you buy will have a percentage of fisetin) per day for five days. It is also lipophilic so taking it with an oil of some kind will promote absorption. I raised the dosage to 1000mg a day since I was doing it for four days and not five. The first two days I emptied the capsules into MCT oil and drank it. The stuff tasted foul and after the first two days I could not face it like that so took it in capsule form with fish oil and an MCT/coconut oil coffee on top. That was better.

Now, on the day following all of this, I don’t yet know what effects it has had beyond the immediate effects of the fast itself. The fisetin might not have been sufficiently bioavailable taken by mouth. It might also be the case, as with exercise, that the best results only show up properly after rest and food. Of course I may see nothing at all. Killing off senescent cells does not turn one into superman, but returns one to a previous normal – while the effects of aging are very gradual indeed.

Book Sale Page Three

Okay, please read this post before contacting me. 

The new copies of Polity Agent and Line War below have gone. One and three on the list below.

Details on contact, postage etc are on my first post about these. Scroll down. Also be aware that some of the books in the previous posts have gone. Sorry to disappoint.

I’ll also add here, just on the off-chance, that I have a load of paperbacks of these in German if anyone is interested. Perhaps some Germans read this, or language students, or someone with other connections to that country?

Book Sale Page Two

Contact details and information regarding postage and packing are on the previous post. Unfortunately the uncorrected proof copy of Polity Agent at the bottom here is now gone. I left that on there just so you will know that if you want something, then order it quickly. As on the previous post: first come first served.

Book Sale!

Page One

Mainly so I can keep track I’m going to put these up over a few days. To the prices here I will have to add postage and packing. Dependent on where you are this can amount to as much as if not more than the price of the book. The last time I did this books went missing in the post, so these will have to be either signed for or tracked or both (I haven’t sorted that out yet). If you follow me on Facebook or Twitter you can contact me there, otherwise neallewisasheratgmaildotcom. First come first served. Please don’t ask me about books that do not or have not yet appeared in these posts.

I will sign the books and write in some message as preferred. You’ll also get one of my home made (signed) bookmarks with each purchase.

Hannibal – Netflix Series

I enjoyed this to begin with as it covered the ground of Red Dragon and expanded on it. The lurid murders, convoluted plots and the psychological interplay between the characters satisfied something in my twisted psyche. The camera work was also excellent with some equally satisfying dream sequences. It was of course utterly fantastical but I did not find it an effort to suspend disbelief. But at the back of my mind resided the sure knowledge that the franchise would be extended and the series would probably die, as many do, by stretching an increasingly meagre plot over many episodes. Then along came series two starting out with a sequence from some months in the future that raised my hopes that this would continue to adhere (loosely) to Red Dragon and that it did have a beginning, middle and then end.

The second season started out well with this, but then came an expansion of the psychobabble, the dream sequences and the ‘artistic’ camera work. These last two kinda reminded me of the new Blade Runner film where art forgot story and went wandering off by itself. It even had the same ramping up of the music volume in an attempt to impart meaning where there was none. But I stuck with it because of that initial sequence. In season three it slid into the plot of the film (and book) Hannibal but with its own particular twist on those. Maybe it would have been okay if someone had reined in the ‘artistic filming’ but I suspect someone told them it was really good so they did more of it. The psychobabble also increased to fill the growing void and segued into the nonsensical. The plot was being stretched thin and hardly covered the holes. A few episodes in I finally gave up. Other viewers also gave up because this was not renewed after the third season.

This is, unfortunately, common in many series I see on Netflix. Franchise extending kills them. Film makers should have the courage to propose series that end rather continue sucking at that teat. At best, if they don’t, what starts out as promising turns into soap opera. The money men and executives behind them should also learn from this growing catalogue of failure. I don’t hold out much hope.

Writing Update

Now checking my journal I see that is was at the end of July when I took a 20,000 word plot thread, extracted from The Warship, and decided to turn it into a short story or perhaps something longer. I mucked about with it for a bit then, cutting away about half of it, and then turning it into something very different. I changed it from third person to first person and ran with it, little concerned about endings, structure or putting together a coherent plot. I would just stay with my protagonist and see where he went.

Inevitably, the human mind always searching for patterns and the author mind always searching for a story, I began to reveal both. Connections began to appear, whether unconsciously created or exposed by chance and I began to impose coherence. My protagonist – a clone sold by some nasty types to the prador for coring and thralling – was called Jack Four. The rest of the clones were Jacks, and Jills, but their story was shorter and not much fun for them. Jack Four then became the working title of something that just kept on growing.

I’ve stated before that my aim when writing a first draft is to write 2,000 words a day five days a week. But for odd days out and one or two rest days I’ve pretty much stuck to that. There’s no doubt now that Jack Four is to be a book since, as of today, it is at 114,000 words (my books range from 125 to 175,000). I seem to be back to the form I had when I wrote the Transformation trilogy.

Jack Four has no enhancements beyond knowledge, loading to his mind from quantum storage crystals in the genetic material from which he was fashioned. He’s human and vulnerable and has a fight on his hands to survive, initially in the prador king’s ship and then elsewhere. Of course I can’t say too much about that ‘elsewhere’, but suffice to say that alien monsters in his future, along with the nasty types who sold him, the prador that bought him, and the question of who he was, in the genetic sense, and who he will become.