Tag: Technology

Gene Therapy

Posted on by Neal Asher

One of our habits/traditions in England has been weekend papers, read in bed (with tea and coffee and cigarettes for a healthy start to the day). Previously we’ve had these delivered but now that delivery costs more than the papers themselves we’ve started going to fetch them. I enjoy a chuckle at Clarkson, read some of the politics, skip over the celebrity stuff then Caroline removes the puzzle pages which we take off to Crete. This morning, out of all the articles about the economy, Europe, whatever, the one that really caught my attention was a small column quite a number of pages in. It was the most important article there and it was about this:
Regulators yesterday approved the first therapy in the western world that can correct errors in a person’s genetic code.
Europe has approved Glybera to be used against a rare inherited disorder which disrupts fat production in the body.
The treatment uses a virus to counteract LPLD, lipoprotein lipase deficiency, which can led to acute inflammation of the pancreas.

I can remember when this was confined to science fiction and the most speculative science articles about what it might be possible to do (Remember that chat between Roy and Tyrell in Bladerunner?). I can remember when this was a future possibility but maybe in ten or fifteen years if massive hurdles could be leapt. This is about changing something as ineluctable as fate: genetic predestination; the hand of cards you were dealt with in the womb and could never change. 

Writing Update: Penny Royal II

Posted on by Neal Asher

Penny Royal II is now past 122,000 words and I’m slowing down a little as I enter the home straight. This is because I have had to go back to alter and add or delete plot elements, even in the previous book, to ensure things lock together. For example, I found it necessary to go back to the start of this book and have a particular entity, with a soft and changing body, undergoing radical surgery to install a ceramal skeleton. Other alterations required are about emphasis. I need to ensure that some King’s Guard warships are seen as very powerful, while an ancient factory station is outdated and vulnerable. I also need to concentrate on the internal life of a particular war drone so the reader understands its motivations.
All this is pretty much a tidying up exercise. When you write fast to produce a massive uproarious story some things fall by the wayside – you drop the ball and have to go back and pick it up. You forget things, like I forgot that a particular prador controlled a number of skeletal Golem, and I also forgot that a Penny Royal Golem is along for the ride. I need to elaborate on how a renegade prador reproduces (incidentally there’s more in this about prador biology and society: prador females, mating, fourth-children). And thinking about the next book, I might have to add something about a black hole and something called ‘the black hole paradox’.

Righto, back to work.

Jawing

Posted on by Neal Asher
I had a bit of a day off yesterday, going off to meet a guy  in a pub on the other side of Maldon – he buys my books every year and every year I sign them. In the morning I spent far too much time reading science articles and generally pissing about on the internet and, in the afternoon, the two beers I had completely wiped out any inclination to work. I won’t bother to try catching up with my weekly word count since being 75,000 words into a book I don’t have to deliver for about one and a half years I can be confident I’m ahead of the game.
Anyway, the writing is going extremely well even with the distractions of the internet, so when we go to Crete at the end of March I expect it will pick up even more. Sickness, death and tragedy aside I can see myself finishing off three books by September 2013.
Despite the beer turning my brain to mush I did read through plenty of science articles yesterday and this one, pointed out to me by Droxxo on the message board, really caught my attention. Here’s a Golem component first manufactured as a human prosthetic:


An 83-year-old woman suffering from a lower jaw infection became the first person to receive a jaw implant manufactured with a 3D printer. Infections such as hers are normally remedied with reconstructive surgery, but doctor’s deemed the procedure too risky because of her age and health. Instead they turned to LayerWise, a company that specializes in 3D printing of metallic structures.
Just, wow.        

The Great Stagnation

Posted on by Neal Asher
Starting from here on The Next Big Future I read a few articles and looked at some videos. The book The Great Stagnation which seems to be at the root of all this makes the claim that technological advance is slowing because we’ve already grabbed the ‘low-hanging fruit’. Take for example the car. It is a huge step to go from not having a car to having one. The car was the big invention and everything since has just been innovation – no flying cars have arrived. In a speech he gives the author of the book cites many examples, like the average kitchen and how little it has changed since the 50s, but he then reluctantly admits that there have been some big advances in communication (Internet, mobile phones etc.).
Apparently, the low hanging fruit having been grabbed means that the average American is half as wealthy as he would have been had the advances been continuing at their previous rate.
Firstly, I don’t buy the distinction between invention and innovation since the car is just an innovation of the horse and cart and can be traced back to Shanks’ pony and the simple need to get from A to B. I sort of buy the ‘low hanging fruit’ argument but in the end that is really a value judgement. Is the invention of the car more important than the invention of the mobile phone? Is it more important than the accumulation of medical inventions/innovations that have extended our lives by decades? Is it more important than sequencing genomes at an increasing rate, biotech that makes it possible to make yeast that produces diesel or our growing nanotechnology? You see what I mean: a value judgement.
And, like many who have been discussing this book, I don’t agree that a slowing of technological advance is why people aren’t as wealthy as they could be. Firstly I don’t agree that technological advances are slowing. I would say that their effects are taking longer to reach us because of an increasingly hysterical anti-science meme that has spread in the West, with its resultant increase in restrictive legislation. Secondly I would say that the decrease in wealth relative to those advances is all due to increasingly parasitic governments and financial institutions sucking up that wealth – wealth that would have been used to develop those technological advances. Invent something astounding and you need big bucks to get it to market from under the leaden hand of government legislation. You don’t have big bucks of your own to spare because government and the financial institutions have stolen them. It’s an increasingly vicious circle.

This is why you see no technological singularity in The Departure – the parasitic state has killed innovation and invention. My only hope, in the real world, is that the financial collapse we are entering now will kill off some portion of the parasite infestation before the host dies. But even if that does happen, the host will still need time to recover its health, and the problem is that parasites grow faster than their hosts. 

Ranting is Habit-Forming.

Posted on by Neal Asher

It’s been my custom in recent years to read ranty blogs in the morning that I was twittering, responding to and getting irate about. Ranting can become a habit, I’ve discovered (No shit!). It can also affect your health both mental and physical. Ranting becomes a fall-back, cringe moments become more frequent, you find yourself spending time putting together bitchy bile-filled responses to people who aren’t going to take any notice anyhow, and end up just feeding their bile too. It also tends to eat up your time and distract you from the things you should be concentrating on. So now I’m trying to break the habit.

I’ve been getting behind on the science, while the science has been accelerating. I’ve been burning up time on ranty shite that would be better spent writing. So what I’ve done is delete the blogs concerned from my favourites, then estimate how much of this stuff I’ve been reading and supplant it with science and technology articles relevant to what I do. (I’m also seeking blogs and websites on English usage, so if you know of any please let me know)

At first it was difficult. I kept feeling the urge to go back and read something bilious because that’s easy, that’s the guy giving up smoking deciding to have one cigarette, just one. That’s the brain getting hard-wired, the habit. Now I’m finding my interest restoring and increasing. By my estimate, to supplant my previous internet reading required about six medium-sized science articles from the likes of Physorg.com, Science Daily and Science News, but now I’m reading about ten or so.

Of course there have been lapses, but not on the usual subjects. Recent comments I made on J. G Ballard lured a Guardianista into attack mode but I laughed that one off when I tweeted his description of my stuff as ‘pornographically violent space opera’ and it sold me some extra books. And I was tempted back on another blog when, in response to a comment of mine about book piracy, the same guy couldn’t resist comparing me to Jeremy Clarkson and the Daily Mail. That he neglected to drop a ‘Thatcher’ in there was almost astounding. I must resist this kind of temptation.

Really, I’m trying to be a better person…      

Thinking About Buying a Smartphone.

Posted on by Neal Asher

Okay, I’m thinking about buying a decent smartphone but, before I waffle on about that, let me get something straight. All I have ever used is a simple mobile phone for making phone calls. The only reason I bothered with one was because in Crete we don’t have a phone line since with the few calls we make it’s hardly worth paying the line rental. It was also the case that doing so was pointless for Internet because, apparently, there was no broadband up in the mountains where we were. (It is possible that there is but OTE didn’t want you to know that, preferring to sell you a year’s dial-up Internet then sell you broadband on top of that. The phone company there is as corrupt as the rest of everything in Greece.)

So, smartphones and what do I want? I’m trying to clarify my thoughts on this and, frankly, I don’t know what these phones are capable of.

I want to be able to get onto the Internet in Internet bars and cafes. I want to be able to twitter and send and receive emails when away from such access and in such circumstances I don’t want to be paying set costs for tweets and emails or be spending a lot of time connected to the Internet through the mobile network.  I want to send all this stuff as text messages (which apparently discounts Virgin and T-Mobile as they are not carriers on Twitter).

I don’t want to have to type these tweets, blogs and emails through the keypad or touchscreen of the phone. I would like to be able to plug it into my laptop where I have typed them, load these to the phone to later send either through the mobile network or Internet connection. In effect I want to use the much more easy-to-use keyboard on my laptop and I don’t want that phone on for long. I don’t want to be tied into a contract; I would rather have pay-as-you-go. This is mainly because I will mainly be using this phone in Crete – I don’t want to be paying monthly for the five months here when I simply won’t use the phone.

What do you think? (And keep it simple)

Science Fiction Singularity

Posted on by Neal Asher

I had gone off Horizon programs because of how dumbed down they’ve been, how so often they were lacking in content – what content they had often being spread over an hour when, if you cut out all the pointless camera shots, they might have filled twenty minutes – and by the frequent righteous environmental preaching. However, I did record one called ‘Playing God’ (a title that put me off straight away), and enjoyed it immensely.   

This was about synthetic biology – essentially genetic modification – and how far advanced it is now. In the program we see the spider goat – a goat that produces a useful spider silk in its milk – and a pre-production plant for making diesel from GM yeast as simply as alcohol is made from the normal kind. The advances are coming at an ever increasing pace what with people being able to do this stuff in home labs. They can buy ‘bricks’ which are chunks of DNA that express certain characteristics, over the Internet, and mix and match them. For example, a bunch of enthusiasts pasted a jellyfish gene into e-coli to make luminescent bacteria – this in the kind of lab any of us could put together in a garden shed.

This is massive; this is a game changer. As the presenter noted this is like Bill Gates putting together a computer in his garage.

Of course the presenter had to whiffle on about the ethics of it all and whether it should be done. All the objections were based on either the Abrahamic religions or the ones springing from the Church of Environmentalism, and of course the terror of change they like to stir up. However, it is far too late to put this one back in the box.

It has been said (well by me at least) that nothing dates faster than science fiction, and this program brought it home to me. In science fiction there’s a lot of talk about various kinds of singularity. It’s usually related to the creation of AI and is seen as an ‘intellectual event horizon, beyond which the future becomes difficult to understand or predict’. It occurs to me that science fiction itself is facing its own singularity of exactly the same kind. We’ve reached the stage now where between writing a book and it being published, part or all of the content of that book can go out of date. Of course with e-books the gap between writing and publishing can be closed but, in maybe just a little time, we’ll reach the point where even as we speculate or extrapolate we will be going out of date, then the point when we’ll simply be well behind the curve.

There has been (for a very long time) much talk about ‘the death of science fiction’.  Maybe that will occur when the need for sensawunda, which we all look for in SF, is supplied by the news every day, or even in our day-to-day lives. If that happens I’m not sure I’ll be particularly upset about it.   

Stem Cell Success

Posted on by Neal Asher

Hitting the sack last night to read for a while I did not get to see the 10.00 o’clock news (probably a good idea) but I did hear some mention of a stem cells success. On Twitter this morning I picked up on a story about two people, who were losing their sight, being treated with embryonic stem cells. One of them, a 51-year old graphic artist who was ‘legally blind’ i.e. could read nothing on an eye-chart, and a 78-year old suffering from macular degeneration.

A week after having cells derived from a days-old embryo injected into her eye, the graphic artist could count fingers, and after one month she could read the top five letters on the eye chart. She can see more colour and contrast, has started using her computer, and for the first time in years can read her watch and thread a needle. The macular degeneration patient recently went to the mall for the first time in years.

There’s some about the possible dangers of using stem cells in the article, how they can differentiate into the wrong sort of cell. I read a story somewhere (which might be apocryphal) of someone being treated for Alzheimer’s and ending up with bone growing inside their brain. Then there are the moral issues. Being an atheist myself and more inclined to the idea that intelligence is more to be valued than species this is not an issue to me. And isn’t it also the case that adult stem cells can now be used and that ways are already being found to multiply them?

This from 2006:
Researchers of the Whitehead Institute have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers tremendous promise for treatments such as bone marrow transplants and perhaps even gene therapy.

“A 30-fold increase is ten times higher than anyone’s achieved before,” says Lodish, senior author on the paper.

Perhaps any biologists here or those who have read up on the subject can elaborate?

Super Massive Black Hole Power Plant

Posted on by Neal Asher

I just love this kind of thinking…



The structures of the power plant basically revolve around the central SMBH in Keplerian motion to form “Dyson Shells.” In an advanced case of Type II, the central star is almost fully covered to form “Dyson Sphere”. Here we discuss the case of structures partly covered, or the Dyson Shell type, and call it a Dyson Sphere. Unlike a stellar environment, or Type II Dyson Sphere, there are complex structures like relativistic jets, accretion disk and accreting matters, rapidly rotating stars, etc., and hence it would be very difficult to construct a fully covered structure, like a system studied by Birch over a large gaseous planet (e.g., Jupiter). However, it is not easy to set numbers of power plants with similar distance orbiting around the central SMBH. Hence, it would be a possible solution to set the power plants on a solid framework, something like structures studied by Birch. Some areas should be kept uncovered to yield emanating jets and accreting flows.

Follow Friday, Apparently

Posted on by Neal Asher

So, I just passed 30,000 words on Penny Royal (having been slowed up over the last two days by feeling crap). The backstory I previously mentioned is now at about 29,000 words and looks likely to turn into a book by itself. What more can I say? Nothing. I don’t want come-backs of the, ‘But you said so-and-so was going to happen’ kind. Everything is up in the air at the moment and I’m just writing where the fancy takes me.

People have been recommending me for a ‘Shorty Award’ on Twitter. After contemplating getting my stilettos out of the wardrobe I realized that this is for ‘producers of the best short content on social media’. Since this is Twitter I’m wondering about the redundancy of the word ‘short’. I went over to the site concerned where there was a questionnaire for me to fill in. I don’t suppose they wanted the kind of answer I gave to their question about a hash tag thingy I would like to see more of: #facesICouldNeverTireOfPunching. Today I’ve discovered that #FF means ‘Follow Friday’ wherein people recommend other people to follow. What a strange introverted place the Twitterverse can be.

Another social media site I’ve signed up on is Google+, but with a sigh, desultory attempts at posting and swift fuck-off flashes of irritation when I encountered problems. I think I’m suffering from social media fatigue #SMF … or something.